How It Works:

5mm Histofreezer Applicator @-55° C

		Have the patient expose the surface to be treated upward.
		Attach a Histofreezer® custom applicator bud to the canister.
		While holding the canister in an upright position, press down on the valve button until the cryogen starts to drip from the bud. Saturation of the bud requires approximately three to five seconds. Then release finger from the valve. (Excess spilled droplets will not harm clothes or office furnishings.)
		Turn the canister horizontally so that the applicator bud is pointing downward and wait 10 to 15 seconds before applying to the lesion. This will allow the bud to reach its effective temperature.
		Apply the frozen applicator bud to the lesion for the recommended time as indicated by the lesion type.

BE CERTAIN THE BUD REMAINS IN A VERTICAL POSITION DURING TREATMENT. TREATMENT AT AN ANGLE OTHER THAN 90º WILL REDUCE THE EFFECTIVENESS OF THE TREATMENT.

The 2mm bud will remain effective (-55ºC) for approximately 90 seconds and the 5mm bud for 120 seconds, allowing you to treat multiple lesions on the same patient with one properly saturated bud. To avoid cross-contamination, do not treat two patients with the same disposable applicator.

A small ring of healthy tissue around the lesion should also be frozen during the process. Freezing begins within a few seconds and may appear as white discoloration of the skin. The patient experiences a tingling/itching feeling and sometimes a slight stinging sensation if the region treated is rich in nerve endings.

Skin will lose its white color a few minutes after the bud has been removed. Erythema, the same size as the frozen region, then appears. Blistering sometimes occurs (possibly blood-filled) within a few days.

Schedule the patient for a return visit in two weeks. This will give the treated area time to slough and repair itself prior to a re-treatment if necessary.